The Cincinnati Reds travel to Seattle for a Wednesday afternoon showdown against the Mariners at T-Mobile Park, with first pitch scheduled for 3:40 PM ET. Brady Singer gets the ball for Cincinnati, squaring off against Seattle's Emerson Hancock in what shapes up as an intriguing interleague matchup. With Elly De La Cruz leading off and a deep lineup backing Singer, the Reds have the pieces in place to grab a road win against a Mariners club that will lean heavily on their home crowd at T-Mobile. The game streams on Reds.TV and airs locally on WLW 700 AM.

Reds at Mariners: Wednesday, July 22, 2026 Game Preview

Brady Singer draws the start for Cincinnati and carries a significant assignment — silencing a Seattle lineup that features legitimate offensive threats up and down the order. Julio Rodríguez slots into the two-hole as Seattle's DH, flanked by Randy Arozarena in the four spot and Cal Raleigh behind the dish. The Mariners are not a lineup Singer can cruise through on autopilot.

On the other side, Emerson Hancock gets the nod for Seattle. The Reds will need to solve him early and often if they want to build any kind of cushion in the later innings.

Cincinnati Reds Starting Lineup at Seattle

• 1. Elly De La Cruz, SS
• 2. Sal Stewart, 1B
• 3. JJ Bleday, LF
• 4. Spencer Steer, RF
• 5. Nathaniel Lowe, DH
• 6. Tyler Stephenson, C
• 7. Dane Myers, CF
• 8. Edwin Arroyo, 2B
• 9. Ke'Bryan Hayes, 3B

Keys to Watch for the Reds

De La Cruz Setting the Table

Elly De La Cruz leading off is the engine that makes this Reds offense run. When he gets on base and uses his elite speed to apply pressure, it changes the game for every hitter behind him. Singer needs run support, and it starts with De La Cruz doing damage at the top of the order against Hancock.

Steer and Lowe Driving in Runs

Spencer Steer in the four-hole and Nathaniel Lowe at DH are the production spots Cincinnati is counting on to do damage in the middle of the lineup. If those two come through with runners on base, Singer's job becomes considerably more manageable.

Singer Navigating the Mariners' Heart of the Order

The stretch of Rodríguez, Canzone, and Arozarena in the two, three, and four slots of Seattle's lineup is where Singer will earn his money Wednesday. Keeping the ball in the park at T-Mobile Park and limiting damage in those at-bats will be the defining factor in how long Singer stays in this game.

Stephenson Commanding the Game Behind the Plate

Tyler Stephenson will be calling Singer's game Wednesday afternoon. A catcher who understands a pitcher's tendencies and keeps him in rhythm can be the difference in a close, low-scoring road game. Stephenson's role is critical.

Prediction

This has the feel of a tight, pitcher-driven game in the Pacific Northwest. Singer is capable of keeping Seattle's lineup off-balance, but the Mariners have real threats in that middle of the order. If De La Cruz reaches base early and Cincinnati's lineup strings together a couple of crooked numbers against Hancock, the Reds have the lineup depth to pull out a road win. Reds 4, Mariners 3.